Conclusions: Three key subelements, nt453-434, nt403-384 and nt283-264 sequence, were successfully identified in the negative regulatory element on hepatitis B virus.
结论:HBV nt453-434、nt403-384和nt283-264序列为HBV nt250-453负性调节元件中发挥关键作用的三个亚元件;这三个亚元件可以独立发挥作用;当以协同的方式发挥作用时,则表现出最强的负性调节作用。
